Intercellular Adhesion Molecule 1 (ICAM1) Lys56Met and Gly241Arg Gene Variants, Plasma-Soluble ICAM1 Concentrations, and Risk of Incident Cardiovascular Events in 23 014 Initially Healthy White Women | Zendy

Robert Y.L. Zee | Zendy; Suzanne Cheng | Zendy; M Kellis | Zendy; Klaus Lindpaintner | Zendy; Nader Rifai | Zendy; Julie E. Buring | Zendy; Paul M. Ridker | Zendy

Open Access

Intercellular Adhesion Molecule 1 (ICAM1) Lys56Met and Gly241Arg Gene Variants, Plasma-Soluble ICAM1 Concentrations, and Risk of Incident Cardiovascular Events in 23 014 Initially Healthy White Women

Author(s) -

Robert Y.L. Zee,

Suzanne Cheng,

M Kellis,

Klaus Lindpaintner,

Nader Rifai,

Julie E. Buring,

Paul M. Ridker

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.490219

Subject(s) - medicine , myocardial infarction , prospective cohort study , cardiology , stroke (engine) , population , mechanical engineering , engineering , environmental health

The objective of this study was to examine the association of 2 nonsynonymous intercellular adhesion molecule 1 (ICAM1) gene variants (Lys56Met and Gly241Arg) with baseline plasma soluble ICAM1 concentrations and with risk of total and selected cardiovascular disease (CVD) events in a prospective cohort of 23 014 apparently healthy white American women followed for 10 years. ICAM1 variations have been associated with plasma soluble ICAM1 concentrations and inflammatory conditions, including atherosclerosis. However, to date, no large prospective, genetic-epidemiological data set is available that would allow evaluation of the degree of association of these gene variants with risk of CVD.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research