Apolipoprotein E in Hypercholesteremia and Beyond | Zendy

Hans H. Dietrich | Zendy

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Apolipoprotein E in Hypercholesteremia and Beyond

Author(s) -

Hans H. Dietrich

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.489856

Subject(s) - apolipoprotein e , medicine , cholesterol , stroke (engine) , pathological , endocrinology , apolipoprotein b , vasomotor , disease , mechanical engineering , engineering

See related article, pages 2136–2141. Apolipoprotein E (ApoE) is a protein related to the receptor-mediated removal of lipids from the blood stream. When ApoE-deficient mice were introduced,1,2 these animals displayed hypercholesteremia and increased atherosclerosis, providing a new tool to study hypercholesteremia-related pathological mechanisms and have been used extensively ever since. With respect to the cerebral circulation, it is interesting to note that not until 1998 did the first study on ApoE deficiency and cerebral ischemia appear3 and only …

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