Association Between Apolipoprotein E Genotype and Carotid Intima-Media Thickness May Suggest a Specific Effect on Large Artery Atherothrombotic Stroke | Zendy

Lavinia Paternoster | Zendy; Nahara Anani Martínez-González | Zendy; Steff Lewis | Zendy; Cathie Sudlow | Zendy

Open Access

Association Between Apolipoprotein E Genotype and Carotid Intima-Media Thickness May Suggest a Specific Effect on Large Artery Atherothrombotic Stroke

Author(s) -

Lavinia Paternoster,

Nahara Anani Martínez-González,

Steff Lewis,

Cathie Sudlow

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.488866

Subject(s) - medicine , apolipoprotein e , intima media thickness , genotype , stroke (engine) , meta analysis , common carotid artery , cardiology , allele , ischemic stroke , disease , carotid arteries , ischemia , genetics , gene , mechanical engineering , biology , engineering

Apolipoprotein E genotype (APOE) influences cholesterol levels and ischemic heart disease. Although there is no convincing overall association with ischemic stroke, APOE may influence large artery (atherothrombotic) stroke, for which carotid intima-media thickness (CIMT) is an informative intermediate phenotype. We therefore performed a systematic review and meta-analysis of the association between APOE and CIMT.

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