Carnosine Is Neuroprotective Against Permanent Focal Cerebral Ischemia in Mice | Zendy

G. K. Rajanikant | Zendy; Daniel Zemke | Zendy; MarieClaude Senut | Zendy; Mark B. Frenkel | Zendy; Alex F. Chen | Zendy; Rishi Gupta | Zendy; Arshad Majid | Zendy

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Carnosine Is Neuroprotective Against Permanent Focal Cerebral Ischemia in Mice

Author(s) -

G. K. Rajanikant,

Daniel Zemke,

MarieClaude Senut,

Mark B. Frenkel,

Alex F. Chen,

Rishi Gupta,

Arshad Majid

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.488502

Subject(s) - carnosine , neuroprotection , ischemia , medicine , pharmacology , brain ischemia , glutathione , anesthesia , antioxidant , oxidative stress , biochemistry , enzyme , biology

Carnosine is a naturally occurring dipeptide with multiple neuroprotective properties. In addition, it is well tolerated in high doses with minimal side effects. The purposes of this study were to determine whether carnosine is neuroprotective in permanent focal cerebral ischemia and to determine potential mechanisms of neuroprotection.

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