Prevention of the Hypercontractile Response to Thrombin by Proteinase-Activated Receptor-1 Antagonist in Subarachnoid Hemorrhage | Zendy

Yasutoshi Kai | Zendy; Katsuya Hirano | Zendy; Yoshihisa Maeda | Zendy; Junji Nishimura | Zendy; Tomio Sasaki | Zendy; Hideo Kanaide | Zendy

Open Access

Prevention of the Hypercontractile Response to Thrombin by Proteinase-Activated Receptor-1 Antagonist in Subarachnoid Hemorrhage

Author(s) -

Yasutoshi Kai,

Katsuya Hirano,

Yoshihisa Maeda,

Junji Nishimura,

Tomio Sasaki,

Hideo Kanaide

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.487769

Subject(s) - medicine , cerebral vasospasm , thrombin , antagonist , contraction (grammar) , subarachnoid hemorrhage , basilar artery , endothelin receptor , downregulation and upregulation , receptor antagonist , thrombin receptor , endothelin 1 , vasospasm , endocrinology , receptor , anesthesia , pharmacology , biochemistry , chemistry , platelet , gene

Cerebral vasospasm is one of the major complications of subarachnoid hemorrhage (SAH). Its pathogenesis still remains elusive, and effective therapeutic strategies are yet to be established. We investigated the role of proteinase-activated receptor-1 (PAR1) in the hypercontractile state in SAH.

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