Open AccessProtein Aggregation and Proteasome Dysfunction After Brain Ischemia
Author(s) -
Pengfei Ge,
Yinan Luo,
Cindy L. Liu,
Bingren Hu
Publication year - 2007
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/strokeaha.107.487108
Subject(s) - proteasome , ischemia , medicine , ubiquitin , western blot , proteolysis , brain ischemia , microbiology and biotechnology , biochemistry , biology , enzyme , gene
Protein unfolding and aggregation are dominant early pathogenic events in neurons after brain ischemia. This study used a transient cerebral ischemia model to investigate whether overproduction of unfolded proteins after brain ischemia is a consequence of proteasome dysfunction.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom