Therapeutic Benefit of Low-Dose Clopidogrel in Patients Undergoing Carotid Surgery Is Linked to Variability in the Platelet Adenosine Diphosphate Response and Patients’ Weight | Zendy

David A. Payne | Zendy; Chris I. Jones | Zendy; Paul D. Hayes | Zendy; A. Ross Naylor | Zendy; Alison H. Goodall | Zendy

Open Access

Therapeutic Benefit of Low-Dose Clopidogrel in Patients Undergoing Carotid Surgery Is Linked to Variability in the Platelet Adenosine Diphosphate Response and Patients’ Weight

Author(s) -

David A. Payne,

Chris I. Jones,

Paul D. Hayes,

A. Ross Naylor,

Alison H. Goodall

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.486787

Subject(s) - clopidogrel , medicine , platelet , aspirin , adenosine diphosphate , placebo , carotid endarterectomy , anesthesia , ticlopidine , platelet activation , stroke (engine) , pharmacology , cardiology , pathology , platelet aggregation , carotid arteries , mechanical engineering , alternative medicine , engineering

We have previously shown that a single 75-mg tablet of clopidogrel, taken before carotid endarterectomy, significantly reduces postoperative embolization, a marker of thromboembolic stroke. This study explores the antiplatelet effect of this submaximal dose.

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