Pioglitazone Exerts Protective Effects Against Stroke in Stroke-Prone Spontaneously Hypertensive Rats, Independently of Blood Pressure | Zendy

Taishi Nakamura | Zendy; Eiichiro Yamamoto | Zendy; Keiichiro Kataoka | Zendy; Takuro Yamashita | Zendy; Yoshiko Tokutomi | Zendy; YiFei Dong | Zendy; Shinji Matsuba | Zendy; Hisao Ogawa | Zendy; Shokei KimMitsuyama | Zendy

Open Access

Pioglitazone Exerts Protective Effects Against Stroke in Stroke-Prone Spontaneously Hypertensive Rats, Independently of Blood Pressure

Author(s) -

Taishi Nakamura,

Eiichiro Yamamoto,

Keiichiro Kataoka,

Takuro Yamashita,

Yoshiko Tokutomi,

YiFei Dong,

Shinji Matsuba,

Hisao Ogawa,

Shokei KimMitsuyama

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.486522

Subject(s) - pioglitazone , medicine , stroke (engine) , blood pressure , endothelial dysfunction , oxidative stress , inflammation , diabetes mellitus , endocrinology , pharmacology , type 2 diabetes , mechanical engineering , engineering

Very recent subgroup analysis from the PROspective pioglitAzone Clinical Trial In macroVascular Events has shown that pioglitazone reduces the risk of recurrent stroke in type 2 diabetic patients. However, the underlying mechanism of stroke prevention by pioglitazone is unknown. Our aim was to examine the effect of pioglitazone on hypertension-based stroke in rats.

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