Transcription Factor Nrf2 Protects the Brain From Damage Produced by Intracerebral Hemorrhage | Zendy

Xiurong Zhao | Zendy; Guanghua Sun | Zendy; Jie Zhang | Zendy; Roger Strong | Zendy; Pramod K. Dash | Zendy; Yuet Wai Kan | Zendy; James C. Grotta | Zendy; Jaroslaw Aronowski | Zendy

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Transcription Factor Nrf2 Protects the Brain From Damage Produced by Intracerebral Hemorrhage

Author(s) -

Xiurong Zhao,

Guanghua Sun,

Jie Zhang,

Roger Strong,

Pramod K. Dash,

Yuet Wai Kan,

James C. Grotta,

Jaroslaw Aronowski

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.486506

Subject(s) - sulforaphane , medicine , intracerebral hemorrhage , oxidative stress , brain damage , cytotoxic t cell , myeloperoxidase , pharmacology , pathogenesis , keap1 , transcription factor , spontaneous intracerebral hemorrhage , immunology , inflammation , anesthesia , cancer research , biochemistry , biology , in vitro , gene , subarachnoid hemorrhage

Intracerebral hemorrhage (ICH) remains a major medical problem for which there is no effective treatment. Oxidative and cytotoxic damage plays an important role in ICH pathogenesis and may represent a target for treatment of ICH. Recent studies have suggested that nuclear factor-erythroid 2-related factor 2 (Nrf2), a pleiotropic transcription factor, may play a key role in protecting cells from cytotoxic/oxidative damage. This study evaluated the role of Nrf2 in protecting the brain from ICH-mediated damage.

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