Confirmation of an Association Between the TNF(−308) Promoter Polymorphism and Stroke Risk in Children With Sickle Cell Anemia | Zendy

Carolyn Hoppe | Zendy; William Klitz | Zendy; Katherine D’Harlingue | Zendy; Suzanne Cheng | Zendy; Michael Grow | Zendy; Lori Steiner | Zendy; Janelle A. Noble | Zendy; Robert J. Adams | Zendy; Lori Styles | Zendy

Open Access

Confirmation of an Association Between the TNF(−308) Promoter Polymorphism and Stroke Risk in Children With Sickle Cell Anemia

Author(s) -

Carolyn Hoppe,

William Klitz,

Katherine D’Harlingue,

Suzanne Cheng,

Michael Grow,

Lori Steiner,

Janelle A. Noble,

Robert J. Adams,

Lori Styles

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.483115

Subject(s) - medicine , sickle cell anemia , stroke (engine) , tumor necrosis factor alpha , anemia , polymorphism (computer science) , ischemic stroke , stroke risk , allele , gene , genetics , disease , ischemia , mechanical engineering , biology , engineering

The etiology of stroke in children with sickle cell anemia (SCA) is complex and poorly understood. Growing evidence suggests that genetic factors beyond the sickle cell mutation influence stroke risk in SCA. We previously reported risk associations with polymorphisms in several proinflammatory genes in SCA children with ischemic stroke. The aim of this replication study was to confirm our previous findings of associations between the TNF(-308) G/A, IL4R 503 S/P, and ADRB2 27 Q/E polymorphisms and large vessel stroke risk.

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