Erythropoietin Promotes Neuronal Replacement Through Revascularization and Neurogenesis After Neonatal Hypoxia/Ischemia in Rats | Zendy

Masanori Iwai | Zendy; Guodong Cao | Zendy; Wei Yin | Zendy; R. Anne Stetler | Zendy; Jialing Liu | Zendy; Jun Chen | Zendy

Open Access

Erythropoietin Promotes Neuronal Replacement Through Revascularization and Neurogenesis After Neonatal Hypoxia/Ischemia in Rats

Author(s) -

Masanori Iwai,

Guodong Cao,

Wei Yin,

R. Anne Stetler,

Jialing Liu,

Jun Chen

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.483008

Subject(s) - medicine , neurogenesis , hypoxia (environmental) , ischemia , erythropoietin , revascularization , stroke (engine) , cardiology , anesthesia , neuroscience , oxygen , chemistry , organic chemistry , myocardial infarction , biology , mechanical engineering , engineering

Erythropoietin (EPO) has been well characterized and shown to improve functional outcomes after ischemic injury, but EPO may also have unexplored effects on neurovascular remodeling and neuronal replacement in the neonatal ischemic brain. The current study investigates the effects of exogenous administration of EPO on revascularization and neurogenesis, 2 major events thought to contribute to neuronal replacement, in the neonatal brain after hypoxia/ischemia (H/I).

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