Neuroprotective Effects of Leptin Against Ischemic Injury Induced by Oxygen-Glucose Deprivation and Transient Cerebral Ischemia | Zendy

Feng Zhang | Zendy; Suping Wang | Zendy; Armando P. Signore | Zendy; Jun Chen | Zendy

Open Access

Neuroprotective Effects of Leptin Against Ischemic Injury Induced by Oxygen-Glucose Deprivation and Transient Cerebral Ischemia

Author(s) -

Feng Zhang,

Suping Wang,

Armando P. Signore,

Jun Chen

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.482786

Subject(s) - medicine , neuroprotection , ischemia , stroke (engine) , transient (computer programming) , oxygen , leptin , anesthesia , ischemic injury , brain ischemia , cardiology , obesity , mechanical engineering , chemistry , organic chemistry , computer science , engineering , operating system

Leptin is the major adipose hormone that regulates body weight and energy expenditure by activating leptin receptors in the hypothalamus. Leptin receptors are also present in other cell types, and a potent antiapoptotic effect for leptin has recently been reported. We investigated whether leptin was neuroprotective against ischemic brain injury.

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