Role of TIMP-1 and TIMP-2 in the Progression of Cerebral Aneurysms | Zendy

Tomohiro Aoki | Zendy; Hiroharu Kataoka | Zendy; Takuya Moriwaki | Zendy; Kazuhiko Nozaki | Zendy; Nobuo Hashimoto | Zendy

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Role of TIMP-1 and TIMP-2 in the Progression of Cerebral Aneurysms

Author(s) -

Tomohiro Aoki,

Hiroharu Kataoka,

Takuya Moriwaki,

Kazuhiko Nozaki,

Nobuo Hashimoto

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.107.481838

Subject(s) - matrix metalloproteinase , aneurysm , extracellular matrix , medicine , tissue inhibitor of metalloproteinase , immunohistochemistry , metalloproteinase , pathology , downregulation and upregulation , messenger rna , microbiology and biotechnology , biology , surgery , gene , biochemistry

The degradation of extracellular matrix (ECM) is a hallmark of a cerebral aneurysm; however, little is known regarding the molecular mechanism leading to this change. Tissue inhibitor of matrix metalloproteinase (TIMP) regulates the ECM degradation in vascular walls by inhibiting the activity of matrix metalloproteinases (MMPs). We investigated the role of TIMPs in the progression of cerebral aneurysms in the present study.

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