Complex Hemodynamics at the Apex of an Arterial Bifurcation Induces Vascular Remodeling Resembling Cerebral Aneurysm Initiation | Zendy

Hui Meng | Zendy; Zhijie Wang | Zendy; Yiemeng Hoi | Zendy; Ling Gao | Zendy; Eleni Metaxa | Zendy; Daniel D. Swartz | Zendy; John Kolega | Zendy

Open Access

Complex Hemodynamics at the Apex of an Arterial Bifurcation Induces Vascular Remodeling Resembling Cerebral Aneurysm Initiation

Author(s) -

Hui Meng,

Zhijie Wang,

Yiemeng Hoi,

Ling Gao,

Eleni Metaxa,

Daniel D. Swartz,

John Kolega

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.106.481234

Subject(s) - hemodynamics , medicine , aneurysm , internal elastic lamina , intimal hyperplasia , anatomy , cardiology , artery , radiology , smooth muscle

Arterial bifurcation apices are common sites for cerebral aneurysms, raising the possibility that the unique hemodynamic conditions associated with flow dividers predispose the apical vessel wall to aneurysm formation. This study sought to identify the specific hemodynamic insults that lead to maladaptive vascular remodeling associated with aneurysm development and to identify early remodeling events at the tissue and cellular levels.

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