Neurocognitive Outcomes Are Not Improved by 17β-Estradiol in Postmenopausal Women Undergoing Cardiac Surgery | Zendy

Charles W. Hogue | Zendy; Kenneth E. Freedland | Zendy; Tamara Hershey | Zendy; Robert Fucetola | Zendy; Abullah Nassief | Zendy; Benico Barzilai | Zendy; Betsy Thomas | Zendy; Stanley J. Birge | Zendy; David Dixon | Zendy; Kenneth B. Schechtman | Zendy; Víctor G. DávilaRomán | Zendy

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Neurocognitive Outcomes Are Not Improved by 17β-Estradiol in Postmenopausal Women Undergoing Cardiac Surgery

Author(s) -

Charles W. Hogue,

Kenneth E. Freedland,

Tamara Hershey,

Robert Fucetola,

Abullah Nassief,

Benico Barzilai,

Betsy Thomas,

Stanley J. Birge,

David Dixon,

Kenneth B. Schechtman,

Víctor G. DávilaRomán

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.106.480426

Subject(s) - medicine , perioperative , placebo , neurocognitive , randomized controlled trial , stroke (engine) , estrogen , anesthesia , surgery , cognition , mechanical engineering , alternative medicine , pathology , psychiatry , engineering

Neurocognitive dysfunction is an important source of patient morbidity and mortality after cardiac surgery that may disproportionately affect postmenopausal women. 17beta-Estradiol limits the extent of ischemic neuronal injury in a variety of experimental models. The purpose of this study was to evaluate whether perioperative administration of 17beta-estradiol to postmenopausal women reduces the frequency of neurocognitive dysfunction after cardiac surgery.

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