Molecular MRI of Cerebral Venous Sinus Thrombosis Using a New Fibrin-Specific MR Contrast Agent | Zendy

Christian Paul Stracke | Zendy; Markus Katoh | Zendy; Andrea J. Wiethoff | Zendy; Edward C. Parsons | Zendy; P. Spangenberg | Zendy; Elmar Spüntrup | Zendy

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Molecular MRI of Cerebral Venous Sinus Thrombosis Using a New Fibrin-Specific MR Contrast Agent

Author(s) -

Christian Paul Stracke,

Markus Katoh,

Andrea J. Wiethoff,

Edward C. Parsons,

P. Spangenberg,

Elmar Spüntrup

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.106.479998

Subject(s) - medicine , superior sagittal sinus , thrombosis , radiology , fibrin , thrombus , magnetic resonance imaging , molecular imaging , cerebral veins , nuclear medicine , in vivo , microbiology and biotechnology , biology , immunology

Imaging of cerebral vein thrombosis is still challenging. Currently, diagnosis is based on CT venography and MRI including MRA and conventional digital subtraction angiography. However, especially in chronic cases, each method has shown its limitations. Newer strategies for MRI are found on molecular imaging using targeted contrast agents. The aim of this study was to prove the feasibility of a novel fibrin-targeted MR contrast agent (EP-2104R; EPIX Pharmaceuticals) for selective imaging of sinus venous thrombosis in an animal model.

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