Src Kinase Inhibition Improves Acute Outcomes After Experimental Intracerebral Hemorrhage | Zendy

Timothy D. Ardizzone | Zendy; Xinhua Zhan | Zendy; Brad Ander | Zendy; Frank R. Sharp | Zendy

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Src Kinase Inhibition Improves Acute Outcomes After Experimental Intracerebral Hemorrhage

Author(s) -

Timothy D. Ardizzone,

Xinhua Zhan,

Brad Ander,

Frank R. Sharp

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.106.478966

Subject(s) - medicine , intracerebral hemorrhage , proto oncogene tyrosine protein kinase src , tunel assay , kinase , endocrinology , pharmacology , anesthesia , receptor , biology , microbiology and biotechnology , immunohistochemistry , subarachnoid hemorrhage

The mechanisms by which intracerebral hemorrhages produce changes of blood flow and metabolism, cell death, and behavioral abnormalities are complex. In this study, we begin to test the hypothesis that intracerebral hemorrhage activates Src kinases that phosphorylate other molecules to produce cell injury and behavioral deficits after intracerebral hemorrhage (ICH).

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