Intravenous Brain-Derived Neurotrophic Factor Enhances Poststroke Sensorimotor Recovery and Stimulates Neurogenesis | Zendy

WolfRüdiger Schäbitz | Zendy; Tobias Steigleder | Zendy; Christiana M. CooperKuhn | Zendy; Stefan Schwab | Zendy; Clemens Sommer | Zendy; Armin Schneider | Zendy; H. Georg Kuhn | Zendy

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Intravenous Brain-Derived Neurotrophic Factor Enhances Poststroke Sensorimotor Recovery and Stimulates Neurogenesis

Author(s) -

WolfRüdiger Schäbitz,

Tobias Steigleder,

Christiana M. CooperKuhn,

Stefan Schwab,

Clemens Sommer,

Armin Schneider,

H. Georg Kuhn

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.106.477331

Subject(s) - neurogenesis , subventricular zone , neurotrophic factors , medicine , brain derived neurotrophic factor , dentate gyrus , neuroscience , stroke (engine) , neuroplasticity , neuroprotection , progenitor cell , stem cell , central nervous system , psychology , biology , receptor , engineering , genetics , mechanical engineering

The discovery of spontaneous neuronal replacement in the adult brain has shifted experimental stroke therapies toward a combined approach of preventing neuronal cell death and inducing neuronal plasticity. Brain-derived neurotrophic factor (BDNF) was shown to induce antiapoptotic mechanisms after stroke and to reduce infarct size and secondary neuronal cell death. Moreover, in intact animals, BDNF is a potent stimulator of adult neurogenesis.

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