The Phosphodiesterase Inhibitor Rolipram Promotes Survival of Newborn Hippocampal Neurons After Ischemia | Zendy

Tsutomu Sasaki | Zendy; Kazuo Kitagawa | Zendy; Emi OmuraMatsuoka | Zendy; Kenichi Todo | Zendy; Yasukazu Terasaki | Zendy; Shiro Sugiura | Zendy; Jun Hatazawa | Zendy; Yoshiki Yagita | Zendy; Masatsugu Hori | Zendy

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The Phosphodiesterase Inhibitor Rolipram Promotes Survival of Newborn Hippocampal Neurons After Ischemia

Author(s) -

Tsutomu Sasaki,

Kazuo Kitagawa,

Emi OmuraMatsuoka,

Kenichi Todo,

Yasukazu Terasaki,

Shiro Sugiura,

Jun Hatazawa,

Yoshiki Yagita,

Masatsugu Hori

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.106.476754

Subject(s) - medicine , rolipram , hippocampal formation , phosphodiesterase , ischemia , pharmacology , stroke (engine) , hippocampus , neuroscience , anesthesia , enzyme , biochemistry , biology , mechanical engineering , chemistry , engineering

Brain ischemia stimulates neurogenesis. However, newborn neurons show a progressive decrease in number over time. Under normal conditions, the cAMP-cAMP responsive element binding protein (CREB) pathway regulates the survival of newborn neurons. Constitutive activation of CREB after brain ischemia also stimulates hippocampal neurogenesis. Thus, activation of cAMP-CREB signaling may provide a promising strategy for enhancing the survival of newborn neurons. We examined whether treatment of mice with the phosphodiesterase-4 inhibitor rolipram enhances hippocampal neurogenesis after ischemia.

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