Early Rise in Serum VEGF and PDGF Levels Predisposes Patients With a NormalMBL2Genotype to Restenosis After Eversion Endarterectomy | Zendy

Attila J. Szabó | Zendy; Judit Laki | Zendy; Hans O. Madsen | Zendy; Edit Dósa | Zendy; Zoltán Prohászka | Zendy; Szabolcs Rugonfalvi-Kiss | Zendy; Márta Kókai | Zendy; György Acsádi | Zendy; István Karádi | Zendy; László Entz | Zendy; L. Selmeci | Zendy; László Romics | Zendy; George Füst | Zendy; Peter Garred | Zendy; László Cervenak | Zendy

Open Access

Early Rise in Serum VEGF and PDGF Levels Predisposes Patients With a NormalMBL2Genotype to Restenosis After Eversion Endarterectomy

Author(s) -

Attila J. Szabó,

Judit Laki,

Hans O. Madsen,

Edit Dósa,

Zoltán Prohászka,

Szabolcs Rugonfalvi-Kiss,

Márta Kókai,

György Acsádi,

István Karádi,

László Entz,

L. Selmeci,

László Romics,

George Füst,

Peter Garred,

László Cervenak

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.106.475954

Subject(s) - medicine , restenosis , vegf receptors , genotype , cardiology , surgery , stent , biochemistry , chemistry , gene

Recently we found that the incidence of restenosis after carotid endarterectomy was significantly higher in patients homozygous for the normal genotype of mannose-binding lectin (MBL2) than in with patients with MBL2 variant genotypes. Several growth factors are also known to contribute to restenosis. Therefore, we investigated whether early postoperative changes in serum vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), and platelet-derived growth factor (PDGF) concentrations and MBL2 genotypes interact in the development of restenosis.

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