Effects of Peroxisome Proliferator-Activated Receptor Ligands in Modulating Tissue Factor and Tissue Factor Pathway Inhibitor in Acutely Symptomatic Carotid Atheromas | Zendy

Jonathan Golledge | Zendy; Simone Mangan | Zendy; Paula Clancy | Zendy

Open Access

Effects of Peroxisome Proliferator-Activated Receptor Ligands in Modulating Tissue Factor and Tissue Factor Pathway Inhibitor in Acutely Symptomatic Carotid Atheromas

Author(s) -

Jonathan Golledge,

Simone Mangan,

Paula Clancy

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.106.474791

Subject(s) - medicine , rosiglitazone , fenofibrate , stroke (engine) , endocrinology , tissue factor , peroxisome proliferator activated receptor , carotid endarterectomy , pharmacology , stenosis , receptor , mechanical engineering , engineering , coagulation

Severely stenotic, symptomatic carotid atheromas are associated with a high risk of stroke in the short term. Although carotid endarterectomy is effective in reducing this stroke risk, it is frequently not applied within the time window for significant benefit. We investigated the effect of peroxisome proliferator-activated receptor (PPAR) -alpha and -gamma ligands in acutely modifying tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in unstable carotid atheromas.

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