Liposome-Encapsulated Hemoglobin Reduces the Size of Cerebral Infarction in the Rat | Zendy

Akira T. Kawaguchi | Zendy; Dai Fukumoto | Zendy; Munetaka Haida | Zendy; Yoshitaka Ogata | Zendy; Mariko Yamano | Zendy; Hideo Tsukada | Zendy

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Liposome-Encapsulated Hemoglobin Reduces the Size of Cerebral Infarction in the Rat

Author(s) -

Akira T. Kawaguchi,

Dai Fukumoto,

Munetaka Haida,

Yoshitaka Ogata,

Mariko Yamano,

Hideo Tsukada

Publication year - 2007

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/strokeaha.106.467290

Subject(s) - medicine , extravasation , hemoglobin , infarction , anesthesia , saline , middle cerebral artery , cerebral infarction , liposome , blood substitute , thrombosis , cerebral cortex , pathology , ischemia , biochemistry , chemistry , myocardial infarction

Liposome-encapsulated hemoglobin (LEH; TRM-645) is a novel oxygen (O(2)) carrier with a lower O(2) affinity (P(50)O(2)=40 mm Hg) than red blood cells. In contrast to cell-free hemoglobin, encapsulation prevents hemoglobin extravasation, whereas its subcellular size (230 nm) may improve O(2) delivery and limit the severity of cerebral infarction.

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