English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

P151 The International Study of Unruptured Intracranial Aneurysms  (ISUIA)Background and Purpose: There are few data  available defining gender-based differences in intracranial aneurysm  (UIA) risk factors and occurrence. The ISUIA provides a unique setting  for evaluating these issues.Methods: Fifty-three centers in  the ISUIA entered 5,669 patients with UIA. 1531 patients are part of a  retrospective follow-up of unoperated UIA between 1970 and 1991.  Another 4,138 comprise a prospective cohort. Half (58%) of this group  are operated and 42% are unnoperated. Data were collected regarding  history of subarachnoid hemorrhage (SAH) and factors including  characteristics of the UIA, family history of stroke, cigarette smoking  and many other demographic and medical history.Results: Combined analysis of these two cohorts revealed that women had a  UIA 3 times more frequently than men (75% vs. 25%). Women had more  multiple aneurysms than men did (52% vs. 42%; p=0.001). Women had a  higher proportion of cavernous and internal carotid artery UIAs  (46.5%) while the men more often had anterior and middle cerebral  artery UIAs (54.5%), p&lt;0.001. Women had an arteriovenous malformation  less frequently than men did (1.6% vs. 3.7%; p=0.001). Cigarette use  was less prevalent in women than men (69% vs. 76%; p=0.001) and  alcohol use was lower in women than men (12.3% vs. 29.8%; p=0.001).  Women were more likely to be hypertensive, (40.3% vs. 36.2%; p=0.02)  and had vascular headache more than men, (27.3% vs. 16.9%; p=0.001).  Age at diagnosis of UIA and family history of aneurysm, SAH, or  indeterminate hemorrhages were similar for men and women. Women in  Group 1 (UIA, no prior SAH) more often used oral contraceptives and  estrogen replacement therapy than women in Group 2 (UIA, prior SAH from  a second aneurysm). Also, Group 1 women more often had a history of  hypertension. Women in Group 2 used cigarettes, alcohol and stimulants  and had a history of vascular headache more often.Conclusions: Women are more likely to harbor UIA than  men. Aneurysm characteristics such as location and multiplicity may  differ, between genders. Selected risk factors for aneurysm formation  may explain these.

Gender Differences in Unruptured Intracranial Aneurysm Formation: Risk Factors and Characteristics