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P102 Objective: Investigate presence of reduced rCBF in  hyperacute ICH using contrast CT.Background: Reduced rCBF  has been reported in ICH. Its extent and precise pattern, however,  remain uncertain. Hyperacute ICH patients are difficult to study as  they are often critically ill. Dynamic CT is rapid, easily performed  and offers superior spatial resolution to PET, SPECT and MRI.Methods: CT scans were performed within 12 hrs of  symptom-onset in 3 acute ICH patients during high-speed injection of  standard iodinated contrast via the antecubital vein. Two 10 mm thick  target sections were imaged continuously for 60 sec. After ICH volumes  were measured, regions of interest (ROIs) for determination of rCBF  were selected in serially expanding 2 mm sections around each hematoma  and compared to similarly measured expanding 2 mm sections around a  hypothetical hematoma in the contralateral hemisphere.Results: Three patients were studied at 3, 8 and 11 hrs post  symptom-onset respectively. Hematoma locations were: putamen (9 ml)  frontal lobe (64 ml) and thalamus (10 ml). Regional CBF (ml/min/100g)  was decreased in the rim of tissue immediately adjacent to the  hematomas (4.2, 2.1, 5.5, respectively) and increased in serially  measured concentric ROIs as they expanded around each hematoma. When  values obtained 2 and 8 mm from the hematoma periphery were compared,  rCBF increased by 440%, 582%, 454%, respectively (graph), compared  to 71%, 128%, 4% in the opposite hemisphere.Conclusion: Single-section dynamic CT is a promising technique for measuring rCBF  around acute intracerebral hematomas. There appears to be a rim of  reduced rCBF surrounding these hematomas. Further study is necessary to  determine its clinical  significance.

Dynamic Single-Section Contrast CT Measures Cerebral Blood Flow in Acute Intracerebral Hemorrhage