Regulation of Arterial Tone by K V 1 Potassium Channels

To the Editor:We have read with interest the recent article published by Circulation Research entitled “Heteromultimeric Kv1 Channels Contribute to Myogenic Control of Arterial Diameter.”1 The study adds to an expanding body of evidence suggesting pivotal roles of the voltage-gated potassium channels (KV channels) in vascular smooth muscle cells as regulators of arterial tone. Nevertheless, we feel it is necessary to point out some issues relating to representation of the literature by Plane et al.A general sentiment conveyed by Plane et al is “This study indicates for the first time the importance of KDR [delayed rectifier potassium] channels composed of KV1 subunits to normal function of arterial resistance vessels via controlling their role in myogenic reactivity.” However, although appropriate references are cited, it is not made apparent to the reader that this concept has been documented previously. For example, Cheong et …