Absence of a NPR-A Gene Functional Deletion Allele in a Postmyocardial Infarction Cohort From New Zealand | Zendy

Barry R. Palmer | Zendy; Chris Frampton | Zendy; Mark Richards | Zendy; Vicky A. Cameron | Zendy; Tomohiro Nakayama | Zendy

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Absence of a NPR-A Gene Functional Deletion Allele in a Postmyocardial Infarction Cohort From New Zealand

Author(s) -

Barry R. Palmer,

Chris Frampton,

Mark Richards,

Vicky A. Cameron,

Tomohiro Nakayama

Publication year - 2004

Publication title -

circulation research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.899

H-Index - 336

eISSN - 1524-4571

pISSN - 0009-7330

DOI - 10.1161/res.94.10.e86

Subject(s) - cohort , population , medicine , family medicine , gerontology , library science , demography , sociology , computer science

To the Editor:Nakayama et al1 have described an interesting polymorphism in the NPR-A gene in a Japanese population. An 8-nucleotide deletion in the 5′ untranslated region (UTR) of the gene was found to be associated with essential hypertension and left ventricular hypertrophy in a study of 200 hypertensive (HT) and 200 normotensive (NT) subjects. The polymorphism occurred at a frequency of 4% in the HT patients and in a single NT subject (0.5%) who was subsequently found to have left ventricular hypertrophy. Carriers of the functional deletion ( D …

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