Open AccessImpact of Arterial Stiffness on All-Cause Mortality in Patients Hospitalized With COVID-19 in Spain
Author(s) -
Enrique Rodilla,
Maria Dolores López-Carmona,
Xavier Cortés,
Lidia Cobos-Palacios,
Sergio Canales,
Maria Carmen Sáez,
Samara Campos Escudero,
Manuel RubioRivas,
Jesús Díez-Manglano,
Santiago J. Freire Castro,
Nuria Vázquez Piqueras,
Elisabeth Mateo Sanchis,
Paula M. Pesqueira-Fontán,
Jeffrey Oskar Magallanes Gamboa,
Andrés González García,
Víctor Madrid Romero,
Lara Tamargo Chamorro,
Julio González Moraleja,
Javier Villanueva Martínez,
Amara González Noya,
Ana Suárez-Lombraña,
Anyuli Gracia Gutiérrez,
Manuel Lorenzo López Reboiro,
JoséManuel RamosRincón,
Ricardo Gómez Huelgas
Publication year - 2021
Publication title -
hypertension
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.986
H-Index - 265
eISSN - 1524-4563
pISSN - 0194-911X
DOI - 10.1161/hypertensionaha.120.16563
Subject(s) - covid-19 , medicine , arterial stiffness , cardiology , intensive care medicine , emergency medicine , blood pressure , disease , virology , outbreak , infectious disease (medical specialty)
Older age and cardiovascular comorbidities are well-known risk factors for all-cause mortality in patients with coronavirus disease 2019 (COVID-19). Hypertension and age are the 2 principal determinants of arterial stiffness (AS). This study aimed to estimate AS in patients with COVID-19 requiring hospitalization and analyze its association with all-cause in-hospital mortality. This observational, retrospective, multicenter cohort study analyzed 12 170 patients admitted to 150 Spanish centers included in the SEMI-COVID-19 Network. We compared AS, defined as pulse pressure ≥60 mm Hg, and clinical characteristics between survivors and nonsurvivors. Mean age was 67.5 (±16.1) years and 42.5% were women. Overall, 2606 (21.4%) subjects died. Admission systolic blood pressure (BP) <120 and ≥140 mm Hg was a predictor of higher all-cause mortality (23.5% and 22.8%, respectively,P <0.001), compared with systolic BP between 120 and 140 mm Hg (18.6%). The 4379 patients with AS (36.0%) were older and had higher systolic and lower diastolic BP. Multivariate analysis showed that AS and systolic BP <120 mm Hg significantly and independently predicted all-cause in-hospital mortality (adjusted odds ratio [ORadj]: 1.27,P =0.0001; ORadj: 1.48,P =0.0001, respectively) after adjusting for sex (males, ORadj: 1.6,P =0.0001), age tertiles (second and third tertiles, ORadj: 2.0 and 4.7,P =0.0001), Charlson Comorbidity Index (second and third tertiles, ORadj: 4.8 and 8.6,P =0.0001), heart failure, and previous and in-hospital antihypertensive treatment. Our data show that AS and admission systolic BP <120 mm Hg had independent prognostic value for all-cause mortality in patients with COVID-19 requiring hospitalization.