Tonin and Kallikrein in the Brain of Transgenic Rat Line Expressing Human Tissue Kallikrein | Zendy

Eliane Sa Lopes Lomez | Zendy; Ronaldo C. Araújo | Zendy; Michael Bäder | Zendy; João Bosco Pesquero | Zendy; Jorge L. Pesquero | Zendy

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Tonin and Kallikrein in the Brain of Transgenic Rat Line Expressing Human Tissue Kallikrein

Author(s) -

Eliane Sa Lopes Lomez,

Ronaldo C. Araújo,

Michael Bäder,

João Bosco Pesquero,

Jorge L. Pesquero

Publication year - 2002

Publication title -

hypertension

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.986

H-Index - 265

eISSN - 1524-4563

pISSN - 0194-911X

DOI - 10.1161/hy0202.104264

Subject(s) - kallikrein , transgene , genetically modified mouse , biology , medicine , endocrinology , gene , microbiology and biotechnology , enzyme , biochemistry

A transgenic rat line harboring the human tissue kallikrein gene was investigated for expression and activity of tonin and kallikrein in different regions of the brain. The introduction of the transgene into the rat genome produced a significant augmentation of the expression levels and activity of rat tissue kallikrein. The possibility that human kallikrein does not hydrolyze the rat substrate is probably responsible for the augmented expression of the rat enzyme. On the other hand, although expression of tonin was significantly reduced, tonin activity was not altered in most brain structures, except for cerebellum and neurohypophysis.

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