Matrix Metalloproteinase Expression Is Related to Hemorrhagic Transformation After Cardioembolic Stroke | Zendy

Joan Montaner | Zendy; José ÁlvarezSabín | Zendy; Carlos A. Molina | Zendy; A. Anglés | Zendy; Sònia Abilleira | Zendy; Juan F. Arenillas | Zendy; Jasone Monasterio | Zendy

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Matrix Metalloproteinase Expression Is Related to Hemorrhagic Transformation After Cardioembolic Stroke

Author(s) -

Joan Montaner,

José ÁlvarezSabín,

Carlos A. Molina,

A. Anglés,

Sònia Abilleira,

Juan F. Arenillas,

Jasone Monasterio

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/hs1201.99512

Subject(s) - medicine , matrix metalloproteinase , ischemia , stroke (engine) , tissue plasminogen activator , t plasminogen activator , middle cerebral artery , hematoma , gastroenterology , pathology , cardiology , surgery , mechanical engineering , engineering

In animal models of cerebral ischemia, matrix metalloproteinase (MMP) expression was significantly increased and related to blood-brain barrier disruption, edema formation, and hemorrhagic transformation (HT). MMP inhibitors reduce HT after embolic ischemia in tissue-type plasminogen activator-treated animals. We aimed to determine the relationship between MMPs and HT after human ischemic stroke.

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