Cerebral Blood Flow in Patients With Chronic Heart Failure Before and After Heart Transplantation | Zendy

Nicolai Gruhn | Zendy; Fin Stolze Larsen | Zendy; S. Boesgaard | Zendy; Gitte M. Knudsen | Zendy; Svend Mortensen | Zendy; G Thomsen | Zendy; Jan Aldershvile | Zendy

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Cerebral Blood Flow in Patients With Chronic Heart Failure Before and After Heart Transplantation

Author(s) -

Nicolai Gruhn,

Fin Stolze Larsen,

S. Boesgaard,

Gitte M. Knudsen,

Svend Mortensen,

G Thomsen,

Jan Aldershvile

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/hs1101.098360

Subject(s) - medicine , heart failure , cardiology , cerebral blood flow , heart transplantation , perfusion , transplantation , cardiac output , hemodynamics , blood flow , anesthesia

Arterial blood pressure and cardiac output are often reduced in patients with chronic heart failure (CHF). Counterregulatory mechanisms with increased neurohormonal activation and changes in the distribution of cardiac output are assumed to secure vital organ perfusion. However, clinical examination of patients with CHF frequently reveals neurological symptoms with dizziness and memory problems, suggesting altered brain perfusion. In this study we determined whether cerebral blood flow (CBF) is reduced in patients with New York Heart Association (NYHA) functional class III and IV (n=12) compared with healthy control subjects (n=12). Furthermore, we examined whether heart transplantation (n=5) could restore CBF.

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