Open AccessHypercholesterolemia Impairs Endothelium-Dependent Relaxations in Common Carotid Arteries of Apolipoprotein E-Deficient Mice
Author(s) -
Livius V. d’Uscio,
Leslie Smith,
Zvonimir S. Katušić
Publication year - 2001
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/hs1101.097393
Subject(s) - endocrinology , medicine , endothelium , acetylcholine , endothelial dysfunction , apolipoprotein e , vasodilation , disease
The effects of Western-type fat diet on endothelium-dependent relaxations and vascular structure in carotid arteries from a mouse model of human atherosclerosis are not known. Our objective was to characterize the mechanisms underlying endothelial dysfunction in apoE-deficient mice.
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