Open AccessGlutamate Injury–Induced Epileptogenesis in Hippocampal Neurons
Author(s) -
David Sun,
Sompong Sombati,
Robert J. DeLorenzo
Publication year - 2001
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/hs1001.097242
Subject(s) - medicine , epileptogenesis , glutamate receptor , hippocampal formation , neuroscience , excitatory amino acid transporter , anesthesia , pharmacology , receptor , biology
Stroke is the major cause of acquired epilepsy. The mechanisms of ischemia-induced epileptogenesis are not understood, but glutamate is associated with both ischemia-induced injury and epileptogenesis in several models. The objective of this study was to develop an in vitro model of epileptogenesis induced by glutamate injury in hippocampal neurons as observed during stroke.
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