Neuronal Expression of the DNA Repair Protein Ku 70 After Ischemic Preconditioning Corresponds to Tolerance to Global Cerebral Ischemia | Zendy

Taku Sugawara | Zendy; Nobuo Noshita | Zendy; Anders Lewén | Zendy; Gyung Whan Kim | Zendy; Pak H. Chan | Zendy

Open Access

Neuronal Expression of the DNA Repair Protein Ku 70 After Ischemic Preconditioning Corresponds to Tolerance to Global Cerebral Ischemia

Author(s) -

Taku Sugawara,

Nobuo Noshita,

Anders Lewén,

Gyung Whan Kim,

Pak H. Chan

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/hs1001.097109

Subject(s) - ischemia , western blot , ischemic preconditioning , hippocampal formation , medicine , dna damage , dna repair , neuroprotection , immunohistochemistry , neuron , dna fragmentation , brain ischemia , microbiology and biotechnology , dna , anesthesia , pathology , pharmacology , endocrinology , biology , programmed cell death , gene , biochemistry , apoptosis , psychiatry

Oxidative stress after ischemia/reperfusion has been shown to induce DNA damage and subsequent DNA repair activity. Ku 70/86, multifunctional DNA repair proteins, bind to broken DNA ends and trigger a DNA repair pathway. We investigated the involvement of these proteins in the development of neuronal tolerance to global cerebral ischemia after ischemic preconditioning.

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