Reversal of Early Diffusion-Weighted Magnetic Resonance Imaging Abnormalities Does Not Necessarily Reflect Tissue Salvage in Experimental Cerebral Ischemia | Zendy

Thomas Ringer | Zendy; Tobias NeumannHaefelin | Zendy; Raymond A. Sobel | Zendy; Michael E. Moseley | Zendy; Midori A. Yenari | Zendy

Open Access

Reversal of Early Diffusion-Weighted Magnetic Resonance Imaging Abnormalities Does Not Necessarily Reflect Tissue Salvage in Experimental Cerebral Ischemia

Author(s) -

Thomas Ringer,

Tobias NeumannHaefelin,

Raymond A. Sobel,

Michael E. Moseley,

Midori A. Yenari

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/hs1001.096058

Subject(s) - medicine , ischemia , glial fibrillary acidic protein , lesion , pathology , magnetic resonance imaging , penumbra , diffusion mri , brain ischemia , effective diffusion coefficient , nuclear medicine , radiology , immunohistochemistry , cardiology

Diffusion-weighted MRI (DWI) can detect early ischemic changes and is sometimes used as a surrogate neurological end point in clinical trials. Recent experimental stroke studies have shown that with brief periods of ischemia, some DWI lesions transiently reverse, only to recur later. This study examined the histological condition of the tissue during the period of DWI reversal.

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