Cyclooxygenase-2 Inhibitor NS-398 Protects Neuronal Cultures From Lipopolysaccharide-Induced Neurotoxicity | Zendy

Eiichi Araki | Zendy; Colleen L. Forster | Zendy; Janet M. Dubinsky | Zendy; M. Elizabeth Ross | Zendy; Costantino Iadecola | Zendy

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Cyclooxygenase-2 Inhibitor NS-398 Protects Neuronal Cultures From Lipopolysaccharide-Induced Neurotoxicity

Author(s) -

Eiichi Araki,

Colleen L. Forster,

Janet M. Dubinsky,

M. Elizabeth Ross,

Costantino Iadecola

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/hs1001.096057

Subject(s) - neurotoxicity , medicine , pharmacology , tumor necrosis factor alpha , programmed cell death , excitotoxicity , proinflammatory cytokine , inflammation , lipopolysaccharide , cyclooxygenase , prostaglandin e2 , prostaglandin e , neuroinflammation , glutamate receptor , immunology , endocrinology , biochemistry , biology , apoptosis , toxicity , receptor , enzyme

The prostanoid-synthesizing enzyme cyclooxygenase (COX)-2 is markedly upregulated after cerebral ischemia and may participate in the mechanisms by which postischemic inflammation contributes to the late stages of ischemic brain injury. In the present study, we sought to provide additional evidence for a role of COX-2 in the mechanisms of neurotoxicity associated with inflammation.

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