Effects of Citicoline on Phospholipid and Glutathione Levels in Transient Cerebral Ischemia | Zendy

Rao Muralikrishna Adibhatla | Zendy; James F. Hatcher | Zendy; Robert J. Dempsey | Zendy

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Effects of Citicoline on Phospholipid and Glutathione Levels in Transient Cerebral Ischemia

Author(s) -

Rao Muralikrishna Adibhatla,

James F. Hatcher,

Robert J. Dempsey

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/hs1001.096010

Subject(s) - citicoline , glutathione , glutathione reductase , medicine , neuroprotection , ischemia , antioxidant , biochemistry , pharmacology , endocrinology , anesthesia , glutathione peroxidase , chemistry , enzyme

Cytidine-5'-diphosphocholine (citicoline or CDP-choline) is an essential intermediate in the biosynthesis of phosphatidylcholine, an important component of the neural cell membrane. Citicoline provided significant neuroprotection after transient forebrain ischemia in gerbils. This study was undertaken to examine changes and effects of citicoline on phospholipids and glutathione synthesis after transient cerebral ischemia and reperfusion.

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