Open AccessEbselen Protects Both Gray and White Matter in a Rodent Model of Focal Cerebral Ischemia
Author(s) -
Hirotaka Imai,
Hiroyuki Masayasu,
Deborah Dewar,
David I. Graham,
I. Mhairi Macrae
Publication year - 2001
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/hs0901.095725
Subject(s) - medicine , ischemia , ebselen , neuroprotection , white matter , pathology , anesthesia , oxidative stress , endocrinology , magnetic resonance imaging , glutathione peroxidase , superoxide dismutase , radiology
The neuroprotective efficacy of an intravenous formulation of the antioxidant ebselen has been comprehensively assessed with specific regard to conventional quantitative histopathology, subcortical axonal damage, neurological deficit, and principal mechanism of action.
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