Increased CD8 + T Cells Associated With Chlamydia pneumoniae in Symptomatic Carotid Plaque | Zendy

Zurab Nadareishvili | Zendy; Deloris E. Koziol | Zendy; Brian A. Szekely | Zendy; Christl Ruetzler | Zendy; Ronald A. LaBiche | Zendy; Richard M. McCarron | Zendy; Thomas J. DeGraba | Zendy

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Increased CD8 ⁺ T Cells Associated With Chlamydia pneumoniae in Symptomatic Carotid Plaque

Author(s) -

Zurab Nadareishvili,

Deloris E. Koziol,

Brian A. Szekely,

Christl Ruetzler,

Ronald A. LaBiche,

Richard M. McCarron,

Thomas J. DeGraba

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/hs0901.095633

Subject(s) - medicine , asymptomatic , chlamydia , cd8 , chlamydophila pneumoniae , cd3 , chlamydiaceae , pathology , immunology , antigen

The presence of Chlamydia pneumoniae has been reported in carotid atheroma, but its causative effect in the activation of an atherosclerotic plaque to a prothrombotic state remains unproved. Antigen- mediated activation of T lymphocytes within plaque may represent a mechanism by which infection can result in plaque conversion. The goal of the present study was to characterize the T-cell subtype profile related to the presence of C pneumoniae in patients with symptomatic versus asymptomatic carotid atherosclerosis.

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