Polymorphisms in Matrix Metalloproteinase-1, -3, -9, and -12 Genes in Relation to Subarachnoid Hemorrhage | Zendy

Baiping Zhang | Zendy; Sahar S. Dhillon | Zendy; Irene Geary | Zendy; W. Martin Howell | Zendy; Fausto Iannotti | Zendy; Ian N. M. Day | Zendy; Shu Ye | Zendy

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Polymorphisms in Matrix Metalloproteinase-1, -3, -9, and -12 Genes in Relation to Subarachnoid Hemorrhage

Author(s) -

Baiping Zhang,

Sahar S. Dhillon,

Irene Geary,

W. Martin Howell,

Fausto Iannotti,

Ian N. M. Day,

Shu Ye

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/hs0901.095382

Subject(s) - subarachnoid hemorrhage , medicine , matrix metalloproteinase , aneurysm , etiology , genotype , population , gene , pathology , bioinformatics , surgery , genetics , biology , environmental health

Intracranial aneurysm, which underlies the vast majority of subarachnoid hemorrhage incidences, has a multifactorial etiology, and the importance of genetic factors is increasingly recognized. Development and rupture of intracranial aneurysms involve degradation and remodeling of the vascular wall matrix in which the matrix metalloproteinases (MMPs) play an important role. The possible impact of MMP gene polymorphisms on susceptibility to intracranial aneurysms is still controversial, with conflicting data from different reported studies.

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