Simvastatin Protects Against Long-Lasting Behavioral and Morphological Consequences of Neonatal Hypoxic/Ischemic Brain Injury | Zendy

Walter Balduini | Zendy; Valerio De Angelis | Zendy; Erika Mazzoni | Zendy; Mauro Cimino | Zendy

Open Access

Simvastatin Protects Against Long-Lasting Behavioral and Morphological Consequences of Neonatal Hypoxic/Ischemic Brain Injury

Author(s) -

Walter Balduini,

Valerio De Angelis,

Erika Mazzoni,

Mauro Cimino

Publication year - 2001

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/hs0901.094287

Subject(s) - neuroprotection , medicine , simvastatin , ischemia , hypoxia (environmental) , anesthesia , brain damage , stroke (engine) , pharmacology , morris water navigation task , hippocampal formation , mechanical engineering , chemistry , organic chemistry , oxygen , engineering

Recent studies suggest that statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) not only reduce the incidence of stroke by lowering cholesterol levels but may also exert neuroprotective effects via a mechanism not related to their lipid-lowering effect. Despite the growing body of evidence, however, the neuroprotective effect of statins in stroke is still controversial. Herein, we studied whether a prophylactic administration of simvastatin (Sim) provides significant protection against brain damage, and we sought to determine its long-lasting behavioral consequences in a neonatal model of hypoxia/ischemia.

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