Involvement of Matrix Metalloproteinase in Thrombolysis-Associated Hemorrhagic Transformation After Embolic Focal Ischemia in Rats | Zendy

Toshihisa Sumii | Zendy; Eng H. Lo | Zendy

Open Access

Involvement of Matrix Metalloproteinase in Thrombolysis-Associated Hemorrhagic Transformation After Embolic Focal Ischemia in Rats

Author(s) -

Toshihisa Sumii,

Eng H. Lo

Publication year - 2002

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/hs0302.104542

Subject(s) - medicine , thrombolysis , ischemia , stroke (engine) , matrix metalloproteinase 9 , cardiology , matrix metalloproteinase , brain ischemia , ischemic stroke , metalloproteinase , myocardial infarction , mechanical engineering , engineering

Thrombolytic therapy with tissue plasminogen activator (tPA) for acute ischemic stroke remains complicated by risks of hemorrhagic transformation. In this study we used a previously established quantitative rat model of tPA-associated hemorrhage to test the hypothesis that matrix metalloproteinases (MMPs) are involved.

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