New Insights Into Brain Damage in Stroke-Prone Rats | Zendy

Uliano Guerrini | Zendy; Luigi Sironi | Zendy; Elena Tremoli | Zendy; Mauro Cimino | Zendy; Bianca Pollo | Zendy; Anna Maria Calvio | Zendy; Rodolfo Paoletti | Zendy; M. Asdente | Zendy

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New Insights Into Brain Damage in Stroke-Prone Rats

Author(s) -

Uliano Guerrini,

Luigi Sironi,

Elena Tremoli,

Mauro Cimino,

Bianca Pollo,

Anna Maria Calvio,

Rodolfo Paoletti,

M. Asdente

Publication year - 2002

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/hs0302.104111

Subject(s) - medicine , stroke (engine) , ischemia , pathological , occlusion , pathology , edema , middle cerebral artery , brain damage , effective diffusion coefficient , magnetic resonance imaging , endocrinology , cardiology , radiology , mechanical engineering , engineering

The spontaneously hypertensive stroke-prone rat (SHRSP) is an animal model for a complex form of cerebrovascular pathology. MRI provides an efficient and noninvasive tool for studying the time course of brain damage. The aim of this study was to gain new insights into the pathological phenomena responsible for the occurrence of brain injury in SHRSP with the use of the apparent diffusion coefficient of water (ADC), one of the most efficient MRI parameters for detecting brain abnormalities. To this end, the pattern of ADC variation observed in SHRSP was compared with that of focal ischemia induced in both SHRSP and Sprague-Dawley rats.

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