Ca 2+ Sparks and Their Function in Human Cerebral Arteries | Zendy

George C. Wellman | Zendy; David J. Nathan | Zendy; Christine M. Saundry | Zendy; Guillermo J. Pérez | Zendy; Adrian D. Bonev | Zendy; Paul L. Penar | Zendy; Bruce I. Tranmer | Zendy; Mark T. Nelson | Zendy

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Ca ²⁺ Sparks and Their Function in Human Cerebral Arteries

Author(s) -

George C. Wellman,

David J. Nathan,

Christine M. Saundry,

Guillermo J. Pérez,

Adrian D. Bonev,

Paul L. Penar,

Bruce I. Tranmer,

Mark T. Nelson

Publication year - 2002

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/hs0302.104089

Subject(s) - iberiotoxin , cerebral arteries , ryanodine receptor , medicine , endoplasmic reticulum , biophysics , middle cerebral artery , myocyte , cerebral circulation , patch clamp , anatomy , electrophysiology , calcium , chemistry , ischemia , biology , biochemistry

Local Ca2+ release events (Ca2+ sparks) caused by the opening of ryanodine-sensitive Ca2+ channels in the sarcoplasmic reticulum have been suggested to oppose constriction in cerebral arteries through the activation of large-conductance Ca2+-activated K+ (BK) channels. We report the first identification and characterization of Ca2+ sparks and associated BK channel currents in smooth muscle cells isolated from human cerebral arteries.

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