Protective Vasomotor Effects of In Vivo Recombinant Endothelial Nitric Oxide Synthase Gene Expression in a Canine Model of Cerebral Vasospasm | Zendy

Vini G. Khurana | Zendy; Leslie Smith | Zendy; Timothy A. Baker | Zendy; Daihiko Eguchi | Zendy; Timothy O’Brien | Zendy; Zvonimir S. Katušić | Zendy

Open Access

Protective Vasomotor Effects of In Vivo Recombinant Endothelial Nitric Oxide Synthase Gene Expression in a Canine Model of Cerebral Vasospasm

Author(s) -

Vini G. Khurana,

Leslie Smith,

Timothy A. Baker,

Daihiko Eguchi,

Timothy O’Brien,

Zvonimir S. Katušić

Publication year - 2002

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/hs0302.103735

Subject(s) - medicine , subarachnoid hemorrhage , cerebral vasospasm , enos , vasospasm , basilar artery , cerebral arteries , middle cerebral artery , anesthesia , pathology , nitric oxide synthase , nitric oxide , ischemia

Post-subarachnoid hemorrhage (SAH) cerebral vasospasm is a potentially devastating condition whose pathogenesis involves impaired nitric oxide (NO) bioavailability. We aimed to determine whether recombinant endothelial NO synthase (eNOS) gene expression may protect vasomotor function and prevent vasospasm in a canine experimental SAH model.

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