Inhibitory Effect With Antisense Mitogen-Activated Protein Kinase Oligodeoxynucleotide Against Cerebral Vasospasm in Rats | Zendy

Motoyoshi Satoh | Zendy; Andrew D. Parent | Zendy; John H. Zhang | Zendy

Open Access

Inhibitory Effect With Antisense Mitogen-Activated Protein Kinase Oligodeoxynucleotide Against Cerebral Vasospasm in Rats

Author(s) -

Motoyoshi Satoh,

Andrew D. Parent,

John H. Zhang

Publication year - 2002

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/hs0302.103734

Subject(s) - mapk/erk pathway , cerebral vasospasm , medicine , basilar artery , subarachnoid hemorrhage , vasospasm , protein kinase a , kinase , pharmacology , biology , microbiology and biotechnology

Mitogen-activated protein kinase (MAPK) may be associated with the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage (SAH). This study aimed to clarify the role of MAPK expression and activation during cerebral vasospasm and to evaluate the therapeutic effect on cerebral vasospasm using an antisense MAPK oligodeoxynucleotide (ODN).

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