Combined Endothelial Nitric Oxide Synthase Upregulation and Caveolin-1 Downregulation Decrease Leukocyte Adhesion in Pial Venules of Ovariectomized Female Rats | Zendy

Roberto A. Santizo | Zendy; Hao-Liang Xu | Zendy; Elena Galea | Zendy; Steve Muyskens | Zendy; Verna L. Baughman | Zendy; Dale A. Pelligrino | Zendy

Open Access

Combined Endothelial Nitric Oxide Synthase Upregulation and Caveolin-1 Downregulation Decrease Leukocyte Adhesion in Pial Venules of Ovariectomized Female Rats

Author(s) -

Roberto A. Santizo,

Hao-Liang Xu,

Elena Galea,

Steve Muyskens,

Verna L. Baughman,

Dale A. Pelligrino

Publication year - 2002

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/hs0202.102363

Subject(s) - enos , downregulation and upregulation , endocrinology , medicine , simvastatin , nitric oxide synthase , ovariectomized rat , nitric oxide , estrogen , endothelium , biology , biochemistry , gene

We recently found that chronic estrogen depletion enhances leukocyte adhesion in pial venules in the female rat, while estrogen repletion decreases it. Estrogen-associated repression of inflammation may be due to upregulation of the endothelial isoform of nitric oxide synthase (eNOS) and concomitant downregulation of the endogenous inhibitor of eNOS, caveolin-1 (CAV-1). In this study we examined the effects of estrogen-independent eNOS upregulation (via simvastatin) and/or CAV-1 downregulation (antisense) on pial venular leukocyte adhesion in ovariectomized (OVX) rats.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research