Variability in Midlife Systolic Blood Pressure Is Related to Late-Life Brain White Matter Lesions | Zendy

Richard J. Havlik | Zendy; Daniel J. Foley | Zendy; Bryan Sayer | Zendy; Kamal Masaki | Zendy; Lon R. White | Zendy; Lenore J. Launer | Zendy

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Variability in Midlife Systolic Blood Pressure Is Related to Late-Life Brain White Matter Lesions

Author(s) -

Richard J. Havlik,

Daniel J. Foley,

Bryan Sayer,

Kamal Masaki,

Lon R. White,

Lenore J. Launer

Publication year - 2002

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/hs0102.101890

Subject(s) - medicine , hyperintensity , blood pressure , atrophy , cardiology , dementia , risk factor , stroke (engine) , magnetic resonance imaging , disease , radiology , mechanical engineering , engineering

Although white matter lesions (WMLs) on brain MRI in older persons are common, the mechanisms are unclear. Besides the associations with advanced age and high blood pressure (BP), variability in systolic BP (SBP) and the resulting changes in blood flow to the deep arteries of the brain may be contributing factors.

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