Open AccessActivation-Induced Resetting of Cerebral Metabolism and Flow Is Abolished by β-Adrenergic Blockade With Propranolol
Author(s) -
Ina K. Schmalbruch,
Rasmus Linde,
Olaf B. Paulson,
Peter Lund Madsen
Publication year - 2002
Publication title -
stroke
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.397
H-Index - 319
eISSN - 1524-4628
pISSN - 0039-2499
DOI - 10.1161/hs0102.101233
Subject(s) - propranolol , blockade , cerebral blood flow , medicine , endocrinology , adrenergic , oxygen , anesthesia , chemistry , receptor , organic chemistry
It has previously been shown that activation will increase cerebral blood flow (CBF) and cerebral glucose uptake (CMR(glc)) in excess of cerebral oxygen uptake (CMRO(2)). Our purpose was to investigate the influence of beta-adrenergic blockade with propranolol on the activation-induced uncoupling of cerebral glucose and oxygen metabolism.
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