Reemergence of Stroke Deficits With Midazolam Challenge | Zendy

Ronald M. Lazar | Zendy; BrianFred Fitzsimmons | Zendy; Randolph S. Marshall | Zendy; Mitchell F. Berman | Zendy; Maria A. Bustillo | Zendy; William L. Young | Zendy; J. P. Mohr | Zendy; Jinesh N. Shah | Zendy; Julie V. Robinson | Zendy

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Reemergence of Stroke Deficits With Midazolam Challenge

Author(s) -

Ronald M. Lazar,

BrianFred Fitzsimmons,

Randolph S. Marshall,

Mitchell F. Berman,

Maria A. Bustillo,

William L. Young,

J. P. Mohr,

Jinesh N. Shah,

Julie V. Robinson

Publication year - 2002

Publication title -

stroke

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.397

H-Index - 319

eISSN - 1524-4628

pISSN - 0039-2499

DOI - 10.1161/hs0102.101222

Subject(s) - medicine , stroke (engine) , midazolam , aphasia , hemiparesis , anesthesia , sedation , neglect , surgery , psychiatry , lesion , mechanical engineering , engineering

Patients who have sustained a neurological injury and then improved may experience transient reemergence of their syndromes when given benzodiazepines. As a step toward assessing whether neurotransmitter systems underlie poststroke clinical improvement, we selected midazolam, a gamma-aminobutyric acid(A) (GABA(A)) agonist, for systemic administration to measure general or stroke-specific effects in patients.

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