Open AccessMinK-Related Peptide 1
Author(s) -
HanGang Yu,
Jie Wu,
Irina A. Potapova,
Rigel T. Wymore,
Ben Holmes,
J. J. Zuckerman,
Z. Pan,
H. Wang,
W. Shi,
R. Robinson,
M. Raafat ElMaghrabi,
Benjamin Wagner,
S. Jeffrey Dixon,
David McKin,
Ira S. Cohen
Publication year - 2001
Publication title -
circulation research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 4.899
H-Index - 336
eISSN - 1524-4571
pISSN - 0009-7330
DOI - 10.1161/hh1201.093511
Subject(s) - mink , peptide , protein subunit , ion channel , beta (programming language) , biology , neuroscience , chemistry , microbiology and biotechnology , biophysics , medicine , endocrinology , biochemistry , receptor , computer science , ecology , gene , programming language
The HCN family of ion channel subunits underlies the currents I(f) in heart and I(h) and I(q) in the nervous system. In the present study, we demonstrate that minK-related peptide 1 (MiRP1) is a beta subunit for the HCN family. As such, it enhances protein and current expression as well as accelerating the kinetics of activation. Because MiRP1 also functions as a beta subunit for the cardiac delayed rectifier I(Kr), these results suggest that this peptide may have the unique role of regulating both the inward and outward channels that underlie cardiac pacemaker activity. The full text of this article is available at http://www.circresaha.org.
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